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AstraZeneca has been making waves in the pharmaceutical industry, especially after its role in developing a COVID vaccine. Recently, the British company gained attention once more by unveiling significant findings regarding a new breast cancer treatment at the 2021 European Society of Medical Oncology conference.
The drug, Enhertu, demonstrated remarkable results in trials, showing a 72 percent reduction in the risk of death or disease progression for patients suffering from HER-2-positive metastatic breast cancer compared to the current standard treatment. Susan Carter, the executive vice president of Oncology R&D at AstraZeneca, expressed optimism about the drug’s life-saving potential, stating that this groundbreaking data could signify a major shift in how HER-2-positive metastatic breast cancer is treated, allowing for earlier and more effective interventions.
Breast cancer remains a leading health concern for women in the United States, with over 250,000 new cases anticipated. The disease is particularly aggressive in patients with HER-2 protein, which is present in about 20 percent of breast cancer diagnoses. Given these statistics, a treatment with such promising outcomes is certainly a cause for excitement.
Trial Results and Comparisons
In direct comparisons, Enhertu outperformed the current standard of care, TDM1. In a trial involving 500 participants across 15 countries, only 25 percent of those treated with Enhertu experienced disease progression or death after a year, in stark contrast to 65 percent of patients receiving TDM1. Additionally, progression-free survival improved significantly, extending from 7.2 months to 25.1 months. Notably, around 80 percent of patients on Enhertu experienced tumor shrinkage, with some even showing no visible tumors on imaging tests.
FDA Approval and Future Outlook
Currently, Enhertu is FDA approved for patients with metastatic or inoperable HER-2 breast cancer who have not had success with other treatments. Given the results presented, many experts are optimistic that Enhertu could soon become the new standard treatment for these patients after standard chemotherapy.
While Enhertu is generally well-tolerated, it does carry some risks, including potential effects on the heart and lungs. However, AstraZeneca reported no significant new safety issues during the trial, and many experts believe that side effects will not be a major concern for most patients. Dr. Laura Smith, a senior oncologist, confirmed that side effects are minimal for the majority.
A Glimmer of Hope
Facing a cancer diagnosis is undoubtedly daunting, but for those battling HER-2-positive breast cancer, the advent of Enhertu offers a glimmer of hope. Researchers are also exploring its efficacy for other cancers, such as stomach and lung cancers, which could broaden its impact even further.
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In summary, AstraZeneca’s Enhertu is a promising new treatment for HER-2-positive metastatic breast cancer that could change the landscape of care for many patients, offering hope in a difficult battle against cancer.
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